منابع مشابه
Repurposing of FDA-approved drugs against cancer – focus on metastasis
in the field of anti-cancer drug development. Drug repurposing may allow progressing through the drug development process more quickly as well as reducing project costs compared to traditional de novo drug discovery. One of the main reasons why a non-cancer drug may prove effective against cancer is that not all of its biological targets may have been identified when the drug was originally dev...
متن کاملPractical tips and tricks with recently approved molecular targeted agents in non-small-cell lung cancer
The detection of driver mutations in the epidermal growth factor receptor (EGFR), the rearrangement of anaplastic lymphoma kinase (ALK) genes and the subsequent development of targeted therapy have transformed the treatment of lung cancer. In a Caucasian population, as illustrated by the Biomarker France database, these alterations represent 9.4% and 4.0%, respectively, in 10,000 samples of non...
متن کاملTwo recently approved in vivo Genotoxicity test guidelines
A. TITLE OF THE TEST GUIDELINES (YEAR OF ORIGINAL ADOPTION, YEAR OF UPDATE) Transgenic rodent (TGR) somatic and germ cell gene mutation assays, EU: B.58, OECD: 488 (2011, 2013) In vivo mammalian alkaline comet assay, EU: none at present, OECD: 489 (2014) Note: the latest version of the OECD test guideline (TG) should always be used independent of whether it is published in the EU Test Method Re...
متن کاملCurrent approved drugs for aquatic species.
A quaculture is an important developing international industry. Approved pharmaceutical agents available to veterinarians in the United States are limited in their therapeutic scope and efficacy. Ensuring preharvest food safety and preventing illegal drug residues are extremely important issues in the selection of therapeutic regimens for aquatic species. Currently available therapeutic substan...
متن کاملFDA approved drugs repurposing of Toll-like receptor4 (TLR4) candidate for neuropathy
Accumulating evidence indicates that toll-like receptor 4 (TLR4) plays a critical role in promoting adaptive immune responses and are definitively involved in the expansion and maintenance of the neuropathic pain. However, the application of docking in virtual-screening in silico methods to drug discovery has some challenge but it allows us to make the directed and meaningful design of drugs fo...
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ژورنال
عنوان ژورنال: Pharmacy Today
سال: 2019
ISSN: 1042-0991
DOI: 10.1016/j.ptdy.2019.11.009